compound introduction
ZK824190 hydrochloride is an orally available and selective urokinase plasminogen activator ( uPA ) inhibitor as a potential treatment for multiple sclerosis. IC 50 s of 237, 1600 and 1850 nM for uPA, tPA, and Plasmin, respectively. In Vivo ZK824190 (2 mg/kg; PO; Rats with EAE model) exhibits a relatively high oral availability and a moderate half time (T 1/2 =2.8 h) . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid
