7-BIA is a receptor-type protein tyrosine phosphatase D (PTPRD) inhibitor with an IC 50 of ~1-3 μM In Vitro 7-BIA (7-butoxy illudalic acid analog) inhibits recombinant human PTPRD and recombinant human PTPRS with IC 50 values of ~1–3 μM and 40 μM, respectively. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo 7-BIA (10-20 mg/kg; given i.p.; only once) reduces cocaine self-administration in highly experienced WT mice . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: WT mice (available cocaine 50 times, 1 mg/kg infusions on FR1 schedule during ≥20 prior sessions) Dosage: 10 mg/kg, 20 mg/kg Administration: Given i.p.; only once Result: Reduced cocaine self-administration in highly experienced WT mice. IC50& Target:IC50: ~1-3 μM (PTPRD), 40 μM (PTPRS)
All
Chemical Reagents
Biomedicine
Organic raw materials
Inorganic chemical industry
intermediate
Agricultural chemicals
Auxiliaries and catalysts
Fragrances and Flavors
Dyes and Pigments
Daily chemical industry
7-BIA
CAS number：1313403-49-4(DMSO) molecular formula：C15H18O6
overview
compound introduction
Specs
| Chinese alias | - | ||
| English alias | - | ||
| CAS number | 1313403-49-4(DMSO) | molecular formula | C15H18O6 |
| molecular weight | 294.30 g/mol | Exact mass | 10mM in DMSO |
| PSA | - | logp | - |
numbering system
No numbering system information yet
physicochemical properties
No physical and chemical property information yet
Safety information
No safety information yet
Production methods and uses
No production method and use information yet
Related
upstream information
No upstream information yet
downstream information
No downstream information yet
MSDS
Found 0 shareMSDS
