BMS-986121 is a positive allosteric modulator (PAM) of the μ opioid receptor extracted from patent WO2014107344. BMS-986121 is built on a chemical scaffold representing a new chemotype for μ receptor PAMs In Vitro BMS-986121 (1 μM~1 mM) significantly augments the β-arrestin–recruitment response produced by a low concentration of endomorphin-I (PAM-detection mode). BMS-986121 significantly increases the inhibition of forskolin-stimulated adenylyl cyclase activity produced by a ∼EC 10 (30 pM) concentration of endomorphin-I in CHOμ cells. BMS-986121 (100 μM) produces leftward shifts in the potency of endomorphin-I (fourfold) and leu-enkephalin (sixfold), in inhibition of forskolin-stimulated cAMP-accumulation assays in CHO-μ cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:μ Opioid Receptor/MOR
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BMS-986121
CAS number：313671-26-0 molecular formula：C15H9Cl2N3O2S
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| Chinese alias | - | ||
| English alias | - | ||
| CAS number | 313671-26-0 | molecular formula | C15H9Cl2N3O2S |
| molecular weight | 366.22 g/mol | Exact mass | ≥98% |
| PSA | - | logp | - |
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