TK05 is a potent and selective inhibitor of leukotriene C 4 synthase (LTC4S) with an IC 50 of 95 nM In Vitro TK05 reduces LTC 4 production in a dose-dependent manner with an IC 50 value of 318 ± 60 nM in MM6 Cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo TK05 (0.12-6 mg/kg; given i.p.; only once) significantly reduces LTE 4 levels . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Zymosan A induced peritonitis mouse model Dosage: 0.12 mg/kg; 6 mg/kg Administration: Given i.p.; only once Result: 0.12 mg/kg of TK05 significantly reduced LTE 4 levels, whereas 6 mg/kg body weight of the compound resulted in almost complete inhibition compared with mice treated with only Zymosan A. IC50& Target:IC50: 95 nM (Leukotriene C 4 synthase)
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TK05
CAS number：1245734-61-5(DMSO) molecular formula：C31H25ClN2O5
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| Chinese alias | - | ||
| English alias | - | ||
| CAS number | 1245734-61-5(DMSO) | molecular formula | C31H25ClN2O5 |
| molecular weight | 540.99 g/mol | Exact mass | 10mM in DMSO |
| PSA | - | logp | - |
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