p-Ethynylphenylalanine hydrochloride (4-Ethynyl-L-phenylalanine hydrochloride) is a potent, selective, reversible and competitive inhibitor of tryptophan hydroxylase (TPH) , with a K i of 32.6 μM In Vitro p-Ethynylphenylalanine hydrochloride selectively and reversibly inhibits the biosynthesis of serotonin. p-Ethynylphenylalanine hydrochloride has a low affinity for various recombinant 5-HT receptors (5-HT 1 , 5-HT 2 , 5-HT 4 , 5-HT 5 , 5-HT 6 , and 5-HT 7 ). MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo p-Ethynylphenylalanine hydrochloride (30 mg/kg; i.p.) decreases in 5-HT and 5-HIAA levels in the rat midbrain but not in tissue . p-Ethynylphenylalanine hydrochloride does not inhibit the aromatic amino acid decarboxylase . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Male Sprague-Dawley rats (200 g) Dosage: 30 mg/kg Administration: Intraperitoneal injection Result: Decreased in 5-HT and 5-HIAA levels in the rat midbrain. IC50& Target:Ki: 32.6 μM (TPH)
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p-Ethynylphenylalanine hydrochloride
CAS number：188640-63-3(DMSO) molecular formula：C11H12ClNO2
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| Chinese alias | 对乙炔基苯丙氨酸盐酸盐 | ||
| English alias | - | ||
| CAS number | 188640-63-3(DMSO) | molecular formula | C11H12ClNO2 |
| molecular weight | 225.67 g/mol | Exact mass | 10mM in DMSO |
| PSA | - | logp | - |
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