K134 is a phosphodiesterase 3 ( PDE3 ) inhibitor. The IC 50 s of K134 toward PDE3A , PDE3B , PDE5 , PDE2 and PDE4 are 0.1, 0.28, 12.1, >300 and >300 µM, respectively. In Vitro K134 (K-134) inhibits rat platelet aggregation induced by collagen and ADP in a dose-dependent manner in vitro. The half-maximal (50%) inhibitory concentration (IC 50 ) values of K134 are 2.5 µM and 3.2 µM, respectively. In vitro experiments, K134 also inhibits mouse platelet aggregation induced by collagen and ADP in a dose-dependent manner, and the IC 50 s are 5.5 µM and 6.7 µM, respectively. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo K134 (K-134) significantly prolongs middle cerebral artery (MCA) occlusion time at doses >10 mg/kg, and reduces cerebral infarct size at 30 mg/kg in the stroke model (n = 12, 87.5±5.6 vs. 126.8±7.5 mm 3 , P Form:Solid IC50& Target:IC50: 0.1 µM (PDE3A), 0.28 µM (PDE3B), 12.1 μM (PDE5)
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K134
CAS number：189362-06-9 molecular formula：C22H29N3O4
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Specs
| Chinese alias | - | ||
| English alias | DTXSID90172346 | K134 compound | K-134 compound | DB12685 | 1-Cyclopropyl-1-((1R,2R)-2-hydroxycyclohexyl)-3-(3-((2-oxo-1,2-dihydroquinolin-6-yl)oxy)propyl)urea | K 134 compound | OPC 33509 | UNII-J9J6NK6W4U | AKOS027337121 | 1-cyclopropyl-1-[(1R,2R)-2-hyd | ||
| CAS number | 189362-06-9 | molecular formula | C22H29N3O4 |
| molecular weight | 399.48 g/mol | Exact mass | ≥99% |
| PSA | 90.900 Ų | logp | 2.2 |
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