CAS number：865305-30-2 molecular formula：C14H17IN4O2
AF-353 (Ro-4) 是一种有效的、选择性的和口服生物利用的 P2X3 receptor 和 P2X2/3 receptor 的拮抗剂，对人P2X3、大鼠P2X3和人P2X2/3的pIC50值分别为8.06、8.05和7.41。 Information AF-353 AF-353 (Ro-4) is a potent, selective and orally bioavailable antagonist of P2X3 receptor and P2X2/3 receptor with pIC50 of 8.06, 8.05 and 7.41 for human P2X3, rat P2X3 and human P2X2/3, respectively. Targets hP2X3 (Cell-free assay); rP2X3 (Cell-free assay); hP2X2/3 (Cell-free assay) 8.06(pIC50); 8.05(pIC50); 7.41(pIC50)
| Chinese alias | - | ||
| English alias | 5-[5-Iodo-4-methoxy-2-(propan-2-yl)phenoxy]pyrimidine-2,4-diamine | 2,4-Pyrimidinediamine, 5-[5-iodo-4-methoxy-2-(1-methylethyl)phenoxy]- | GTPL4125 | S0405 | BDBM50257636 | F0516 | SS-4681 | AKOS026750345 | (4-(morpholinomethyl)pbenyl)boronic acid | AF-3 | ||
| CAS number | 865305-30-2 | molecular formula | C14H17IN4O2 |
| molecular weight | 400.21 g/mol | Exact mass | - |
| PSA | 96.300 Ų | logp | 2.934 |
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