Information NIK SMI1 NIK SMI1 is a highly potent and selective NF-κB-inducing kinase (NIK) inhibitor with Ki of 0.23 nM for NIK-catalyzed hydrolysis of ATP to ADP. Targets NIK-catalyzed hydrolysis of ATP to ADP 0.23 nM(Ki) In vitro NIK SMI1 exhibits selective inhibition of LTβR-dependent p52 translocation and transcription of NF-κB2 related genes. NIK SMI1 is shown to have a favorable pharmacokinetic profile across species and to inhibit BAFF-induced B cell survival in vitro. In vivo NIK SMI1 inhibits BAFF signaling and reduces splenic marginal zone B cells in vivo. Cell Research(from reference) Cell lines：293 cells, HeLa cells, SF9 cell line, Human B cells, Mouse B cells Concentrations：1 μM, different concentrations Incubation Time：24 h, 5 h
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NIK SMI1
CAS number：1660114-31-7 molecular formula：C2OH19N3O4
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| Chinese alias | - | ||
| English alias | (R)-6-(3-((3-Hydroxy-1-methyl-2-oxopyrrolidin-3-yl)-ethynyl)phenyl)-4-methoxypicolinamide, 6-[3-[2-[(3R)-3-Hydroxy-1-methyl-2-oxo-3-pyrrolidinyl]ethynyl]phenyl]-4-methoxy-2-pyridinecarboxamide, NIK small molecule inhibitor 1 | ||
| CAS number | 1660114-31-7 | molecular formula | C2OH19N3O4 |
| molecular weight | 365.38 g/mol | Exact mass | - |
| PSA | 106.000 Ų | logp | 0.9 |
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