compound introduction
SAR131675是一种VEGFR3抑制剂，无细胞试验中IC50/Ki为23 nM/12 nM，作用于VEGFR3比作用于VEGFR1/2选择性高50和10倍，对Akt1， CDKs， PLK1， EGFR， IGF-1R， c-Met， Flt2等几乎没有作用活性。
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SAR131675
CAS number：1433953-83-3 molecular formula：C18H22N4O4
overview
Specs
| Chinese alias | - | ||
| English alias | (R)-2-amino-1-ethyl-7-(3-hydroxy-4-methoxy-3-methylbut-1-ynyl)-N-methyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxamide | (R)-2-amino-1-ethyl-7-(3-hydroxy-4-methoxy-3-methylbut-1-yn-1-yl)-N-methyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxamide | ||
| CAS number | 1433953-83-3 | molecular formula | C18H22N4O4 |
| molecular weight | 358.39 g/mol | Exact mass | ≥98% |
| PSA | 118.000 Ų | logp | 1.1 |
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