CAS number：1214265-56-1 molecular formula：C24H25ClN6O2
WZ3146是不可逆的EGFR(L858R)和EGFR(E746_A750)突变选择型抑制剂，IC50均为2 nM，对ERBB2磷酸化(T798I)无抑制性。A mutant EGFR phosphorylation inhibitor WZ3146 is a mutant-selective irreversible inhibitor of EGFR(L858R) and EGFR(E746_A750) with IC50 of 2 nM and 2 nM; does not inhibit ERBB2 phosphorylation (T798I). A mutant EGFR phosphorylation inhibitor
| Chinese alias | - | ||
| English alias | A891789 | n',n'-diisopropyl-ethane-1,2-diamine | AS-55862 | N-[3-[5-chloro-2-[4-(4-methylpiperazin-1-yl)anilino]pyrimidin-4-yl]oxyphenyl]prop-2-enamide | STL377914 | SW219394-1 | D70853 | N-[3-({5-Chloro-2-[4-(4-methylpiperazin-1-yl)anilino]pyrimidin-4-yl | ||
| CAS number | 1214265-56-1 | molecular formula | C24H25ClN6O2 |
| molecular weight | 464.96 g/mol | Exact mass | ≥98% |
| PSA | 82.600 Ų | logp | 4.3 |
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