compound introduction
BMS-777607 (BMS 817378)是一种Met相关的抑制剂，作用于c-Met，Axl，Ron和Tyro3，在无细胞试验中IC50分别为3.9 nM，1.1 nM，1.8 nM和4.3 nM，作用于Met相关靶点比作用于Lck， VEGFR-2，和TrkA/B选择性高40倍，比作用于其他受体和非受体激酶选择性高500多倍。
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BMS-777607
CAS number：1025720-94-8 molecular formula：C25H19ClF2N4O4
overview
Specs
| Chinese alias | - | ||
| English alias | FT-0701277 | SCHEMBL2588311 | 3-Pyridinecarboxamide, N-[4-[(2-amino-3-chloro-4-pyridinyl)oxy]-3-fluorophenyl]-4-ethoxy-1-(4-fluorophenyl)-1,2-dihydro-2-oxo- | N-{4-[(2-amino-3-chloropyridin-4-yl)oxy]-3-fluorophenyl}-4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-d | ||
| CAS number | 1025720-94-8 | molecular formula | C25H19ClF2N4O4 |
| molecular weight | 512.89 g/mol | Exact mass | - |
| PSA | 107.000 Ų | logp | 4 |
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