CAS number：1374640-70-6 molecular formula：C27H28F3N7O3
CO-1686 (AVL-301)是一种不可逆的，突变选择性的EGFR抑制剂，作用于EGFRL858R/T790M和EGFRWT， Ki分别为21.5 nM和303.3 nM。Phase 2。 CO-1686 is an irreversible, mutant-selective EGFR inhibitor with Ki of 21.5 nM and 303.3 nM for EGFRL858R/T790M and EGFRWT, respectively. Phase 2.
| Chinese alias | - | ||
| English alias | NSC779405 | NSC-779405 | s7284 | NCGC00386293-08 | SB16488 | HUFOZJXAKZVRNJ-UHFFFAOYSA-N | CO1686 | CO-1686 | DB11907 | DTXSID801025958 | Tox21_111814 | CO-1686(Rociletinib) | EINECS 233-234-9 | HMS3653G08 | SCHEMBL4177736 | Rociletinib (CO-1686, AVL-301) | ||
| CAS number | 1374640-70-6 | molecular formula | C27H28F3N7O3 |
| molecular weight | 555.55 g/mol | Exact mass | - |
| PSA | 112.000 Ų | logp | 4 |
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