CAS number：882663-88-9 molecular formula：C29H28F3N5O2
Information AMG-47a AMG-47a is a potent, nonselective inhibitor of Lck kinase with IC50 of 3.4 uM and it also inhibits T cell proliferation. AMG-47a exhibit anti-inflammatory activity (ED50) of 11 mg/kg in the anti-CD3-induced production of interleukin-2 (IL-2) in mice. Targets LCK (Cell-free assay) 3.4 μM
| Chinese alias | - | ||
| English alias | AMG-47a | 882663-88-9 | 4-methyl-3-(2-((2-morpholinoethyl)amino)quinazolin-6-yl)-N-(3-(trifluoromethyl)phenyl)benzamide | 4-methyl-3-[2-(2-morpholin-4-ylethylamino)quinazolin-6-yl]-N-[3-(trifluoromethyl)phenyl]benzamide | CHEMBL215943 | AMG-47 | 4-methyl- | ||
| CAS number | 882663-88-9 | molecular formula | C29H28F3N5O2 |
| molecular weight | 535.56 g/mol | Exact mass | 2mM in DMSO |
| PSA | 79.400 Ų | logp | 5.275 |
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