FIIN-2是一种不可逆的泛-FGFR抑制剂，对FGFR1/2/3/4的IC50分别为3.09 nM，4.3 nM，27 nM 和 45.3 nM。 Information FIIN-2 is an irreversible, pan-FGFRinhibitor withIC50of 3.09 nM, 4.3 nM, 27 nM and 45.3 nM for FGFR1/2/3/4, respectively. Targets FGFR1 (Cell-free assay); FGFR2 (Cell-free assay); FGFR3 (Cell-free assay); FGFR4 (Cell-free assay) 3.09 nM; 4.3 nM ;27 nM; 45.3 nM In vitro In FGFR1-4 Ba/F3 cells, FIIN-2 inhibits cell proliferation with EC50 in the single- to double-digit nanomolar range. FIIN-2 also shows excellent antiproliferative activity in a variety of backgrounds, including cell lines that have gatekeeper mutations in FGFR1 and that are dependent on FGFR4. In vivo In a zebrafish developmental model, FIIN-2 causes mild or severe phenotypes to the tail morphogenesis by inhibiting FGFR. Cell Research(from reference) Cell lines：NCI-H2077, NCI-H1581, H520, Kato III, AN3CA, RT112, A2780, 4T1, and SKOV-3 cells Concentrations：1.0 μM Incubation Time：96 h
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FIIN-2
CAS number：1633044-56-0 molecular formula：C35H38N8O4
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| Chinese alias | FIIN2；CHEMBL4065323 | ||
| English alias | N-[4-[[3-(3,5-dimethoxyphenyl)-3,4-dihydro-7-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-2-oxopyrimido[4,5-d]pyrimidin-1(2H)-yl]methyl]phenyl]-2-Propenamide；N-(4-((3-(3,5-Dimethoxyphenyl)-7-((4-(4-methylpiperazin-1-yl)phenyl)am | ||
| CAS number | 1633044-56-0 | molecular formula | C35H38N8O4 |
| molecular weight | 634.73 g/mol | Exact mass | 10mM in DMSO |
| PSA | 115.000 Ų | logp | 4.000 |
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