All
Chemical Reagents
Biomedicine
Organic raw materials
Inorganic chemical industry
intermediate
Agricultural chemicals
Auxiliaries and catalysts
Fragrances and Flavors
Dyes and Pigments
Daily chemical industry

EAI045

CAS number：1942114-09-1    molecular formula：C19H14FN3O3S

overview
Specs
numbering system
physicochemical properties
Safety information
Production methods and uses
Related
MSDS
related products

overview

compound introduction

EAI045是一种靶向特定耐药性的EGFR突变体的变构抑制剂。对野生型受体无作用。 EAI045是突变体 EGFR 的第四代变构抑制剂，在10 μM ATP时抑制EGFR，EGFRL858R，EGFRT790M 和 EGFRL858R/T790M 的IC50 值分别为1.9，0.019，0.19 和 0.002 μM。

Specs

Chinese alias-
English alias2H-​Isoindole-​2-​acetamide,α-​(5-​fluoro-​2-​hydroxyphenyl)​-​1,​3-​dihydro-​1-​oxo-​N-​2-​thiazolyl- | (Z)-2-(5-fluoro-2-hydroxyphenyl)-2-(1-oxoisoindolin-2-yl)-N-(thiazol-2-yl)acetimidic acid
CAS number1942114-09-1molecular formulaC19H14FN3O3S
molecular weight383.4 g/molExact mass-
PSA111.000 Ųlogp2.700

numbering system

No numbering system information yet

physicochemical properties

No physical and chemical property information yet

Safety information

No safety information yet

Production methods and uses

No production method and use information yet

Related

upstream information

No upstream information yet

downstream information

No downstream information yet

MSDS

Found 0 shareMSDS