CAS number：1254473-64-7 molecular formula：C21H19Cl2N5O2
LY2874455是一个泛FGFR的抑制剂，对FGFR1，FGFR2, FGFR3, 和FGFR4的IC50值分别为2.8 nM, 2.6 nM, 6.4 nM,以及6 nM。并且也能抑制VEGFR2的活性，IC50为7 nM。Phase 1。 LY2874455 is a pan-FGFR inhibitor with IC50 of 2.8 nM, 2.6 nM, 6.4 nM, and 6 nM for FGFR1, FGFR2, FGFR3, and FGFR4, respectively, and also inhibits VEGFR2 activity with IC50 of 7 nM. Phase 1.
| Chinese alias | - | ||
| English alias | 7-Chloro-1,3-dihydro-5-(o-chlorophenyl)-3-hydroxy-1-methyl-2H-1,4-benzodiazepin-2-one | C18374 | (R,E)-2-(4-(2-(5-(1-(3,5-dichloropyridin-4-yl)ethoxy)-1H-indazol-3-yl)vinyl)-1H-pyrazol-1-yl)ethan-1-ol | BCP04756 | LY2874455 | LY-2874455 | BCP0726000015 | | ||
| CAS number | 1254473-64-7 | molecular formula | C21H19Cl2N5O2 |
| molecular weight | 444.31 g/mol | Exact mass | - |
| PSA | 88.900 Ų | logp | 3.500 |
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