I-OMe-Tyrphostin AG 538 (I-OMe-AG 538) is a specific inhibitor of IGF-1R (insulin-like growth factor-1 receptor tyrosine kinase). I-OMe-Tyrphostin AG 538 inhibits IGF-1R-mediated signaling and is preferentially cytotoxic to nutrient-deprived PANC1 cells. I-OMe-Tyrphostin AG 538 is an ATP-competitive inhibitor of phosphatidylinositol-5-phosphate 4-kinase α (PI5P4Kα) , with an IC 50 of 1 µM In Vitro I-OMe-Tyrphostin AG 538 (I-OMe-AG 538) (0.1-1000 µM; 24 hours) is cytotoxic to PANC-1 cells in nutrient-deprived medium. I-OMe-Tyrphostin AG 538 (0-3 µM; 1 hour) blocks phosphorylation of IGF-1R, Akt and Erk. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability AssayCell Line: PANC-1 cells Concentration: 0.1, 1, 10, 1000 µM Incubation Time: 24 hours Result: Cytotoxic to PANC-1 cells in nutrient-deprived medium. Western Blot AnalysisCell Line: PANC-1 cells (stimulation with 50 ng/ml IGF-1 for 10 min) Concentration: 0.03, 0.3, 3 µM Incubation Time: 1 hour Result: Blocked phosphorylation of IGF-1R, Akt and Erk. Form:Solid IC50& Target:IC50: 1 µM (PI5P4Kα)
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I-OMe-Tyrphostin AG 538
CAS number：1094048-77-7 molecular formula：C17H12INO5
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| Chinese alias | I-OMe-酪氨酸磷酸化抑制剂 AG 538 | ||
| English alias | cid_5353685 | HMS2233K08 | HY-135680 | MS-27833 | Nasol | (E)-3-(4-hydroxy-3-iodo-5-methoxy-phenyl)-2-protocatechuoyl-acrylonitrile | NCGC00016053-04 | I-OMe-Tyrphostin AG 538, solid | HMS3263L04 | NCGC00094491-01 | SCHEMBL29997 | BDBM60983 | LY-307640 | | ||
| CAS number | 1094048-77-7 | molecular formula | C17H12INO5 |
| molecular weight | 437.19 g/mol | Exact mass | ≥99% |
| PSA | 111.000 Ų | logp | 3.2 |
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