compound introduction
JAK-IN-25 (compound 19) is a potent JAK inhibitor with IC 50 s of 6 nM, 21 nM, 8 nM, 1051 nM for TYK2 , JAK1 , JAK2 , JAK3 , respectively. JAK-IN-25 inhibits human whole blood IL-12 (HEB IL-12) with an IC 50 of 28 nM. JAK-IN-25 has the potential for cancer research Form:Solid IC50& Target:Tyk2 6 nM (IC 50 ) JAK1 21 nM (IC 50 ) JAK2 8 nM (IC 50 ) JAK3 1051 nM (IC 50 )
