Triciferol functions as a multiple ligand with combined VDR agonist and HDAC antagonist activities. Triciferol binds directly to the VDR ( IC 50 =87 nM), and functions as an agonist with 1,25D-like potency on several 1,25D target genes. Triciferol induces marked tubulin hyperacetylation, and augments histone acetylation. Antiproliferative and cytotoxic activities. In Vitro Triciferol (0-10000 nM; 0-72 hours) is significantly more efficacious in suppressing the proliferation of estrogen receptor-negative human MDA-MB231 breast cancer cells. Treatment of MCF-7 cells with Triciferol (100-1000 nM) induces ≈2.5-fold higher rates of cell death than equimolar amounts of 1,25D. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Proliferation AssayCell Line: MDA-MB231 breast cancer cells Concentration: 0-10000 nM Incubation Time: 0-72 hours Result: Growth inhibition was statistically significantly different from that of 1,25D at concentrations of 1 nM or above. Form:Solid
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Triciferol
CAS number：957214-00-5 molecular formula：C26H39NO4
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| Chinese alias | 三苯醇 | ||
| English alias | - | ||
| CAS number | 957214-00-5 | molecular formula | C26H39NO4 |
| molecular weight | 429.59 g/mol | Exact mass | ≥98% |
| PSA | - | logp | - |
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