CAS number：2589531-76-8 molecular formula：C22H26N6O2
Saruparib (AZD5305) 是一种口服有效的，具有选择性的多聚 ADP 核糖聚合酶抑制剂和捕集剂，对 PARP1 和 PARP2 的 IC50 值分别为 3 nM 和 1400 nM。Saruparib 具有抗增殖活性，并抑制 DNA 修复缺陷细胞的生长。 Saruparib (AZD5305) is a potent, orally active and selective PARP inhibitor and trapper with IC50 values of 3 nM and 1400 nM for PARP1 and PARP2, respectively. Saruparib has anti-proliferative activity and inhibits growth in cells with deficiencies in DNA repair.
| Chinese alias | 5-(4-((7-乙基-6-氧代-5,6-二氢-1,5-萘啶-3-基)甲基)哌嗪-1-基)-N-甲基吡啶-2-酰胺 | 沙鲁帕利布 | ||
| English alias | HY-132167 | saruparib [INN] | Azd 5305 | 2589531-76-8 | SY295016 | 2-Pyridinecarboxamide, 5-(4-((7-ethyl-5,6-dihydro-6-oxo-1,5-naphthyridin-3-yl)methyl)-1-piperazinyl)-N-methyl- | EX-A5234 | MS-26971 | NSC834196 | NSC-834196 | SCHEMBL22912701 | 5-(4-((7-E | ||
| CAS number | 2589531-76-8 | molecular formula | C22H26N6O2 |
| molecular weight | 406.48 g/mol | Exact mass | ≥98% |
| PSA | 90.500 Ų | logp | 1.1 |
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