Mouse MARC, a member of the beta subfamily of chemokines, was initially identified as a transcript that is induced in a mouse mast cell line after Fc epsilon RI triggering by IgE plus antigen. Sequence comparisons suggest that MARC may be the mouse homologue of the human MCP-3 gene. Mouse MARC/MCP-3 expression has also been detected during murine experimental allergic encephalomyelitis in the spinal cord, and in LPS-stimulated murine WEHI -3 cells and Swiss 3T3 cells where MARC expression is glucocorticoid-attenuated. Except for one amino acid subsititution, mouse MARC is identical to mouse FIC, the product of a growth factor-activated gene. The mouse MARC cDNA encodes a 97 amino acid residue precursor protein with a 23 amino acid residue signal peptide that is cleaved to yield a 74 amino acid residue mature protein. Mouse CCR2, a mouse chemokine receptor, has been shown to bind JE/MCP-1 with high affinity and MARC/MCP-3 with lower affinity. The E. coli-expressed mouse MARC/MCP-3 produced at R&D Systems has been shown to be a monocyte and T-lymphocyte chemoattractant.
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Recombinant Mouse CCL7/MARC Protein
CAS number：unknown molecular formula：
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Specs
| Chinese alias | 重组小鼠CCL7蛋白 | 重组小鼠MARC蛋白 | 重组小鼠趋化因子配体7蛋白 | ||
| English alias | C-C motif chemokine 7 | CCL7 | chemokine (C-C motif) ligand 7 | FIC | MARC | MCP-3 | MCP3Monocyte chemotactic protein 3 | MCP-3Small-inducible cytokine A7 | MGC138465 | Monocyte chemoattractant protein 3 | NC28SCYA6 | SCYA7MGC138463 | small inducible cyto | ||
| CAS number | unknown | molecular formula | |
| molecular weight | - | Exact mass | 无载体 |
| PSA | - | logp | - |
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