Purity >98% by SDS-PAGE and HPLC analyses. Function Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. Binds to CCR1, CCR3, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant RANTES protein induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form RANTES(3-68) acts as a natural chemotaxis inhibitor and is a more potent inhibitor of HIV-1-infection. The second processed form RANTES(4-68) exhibits reduced chemotactic and HIV-suppressive activity compared with RANTES(1-68) and RANTES(3-68) and is generated by an unidentified enzyme associated with monocytes and neutrophils.
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Recombinant Human RANTES Protein
CAS number：unknown molecular formula：
overview
compound introduction
Specs
| Chinese alias | 重组人RANTES蛋白 | 重组人类RANTES蛋白 | ||
| English alias | CCL5 | chemokine (C-C motif) ligand 5 | D17S136Enormally T-expressed, and presumably secreted | EoCP | Eosinophil chemotactic cytokine | RANTES | SISd | SIS-delta | small inducible cytokine A5 (RANTES) | small inducible cytokine subfamily A (Cys-Cys), mem | ||
| CAS number | unknown | molecular formula | |
| molecular weight | - | Exact mass | 无动物源 |
| PSA | - | logp | - |
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