Hydrolyzes lysophospholipids to produce lysophosphatidic acid (LPA) in extracellular fluids. Major substrate is lysophosphatidylcholine. Also can act on sphingosylphosphphorylcholine producing sphingosine-1-phosphate, a modulator of cell motility. Can hydrolyze, in vitro, bis-pNPP, to some extent pNP-TMP, and barely ATP. Involved in several motility-related processes such as angiogenesis and neurite outgrowth. Acts as an angiogenic factor by stimulating migration of smooth muscle cells and microtubule formation. Stimulates migration of melanoma cells, probably via a pertussis toxin-sensitive G protein. May have a role in induction of parturition. Possible involvement in cell proliferation and adipose tissue development. Tumor cell motility-stimulating factor.
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Recombinant Human ENPP-2/Autotaxin Protein
CAS number：unknown molecular formula：
overview
compound introduction
Specs
| Chinese alias | 外核苷酸焦磷酸酶/磷酸二酯酶2(ENPP2)重组蛋白 | ||
| English alias | Autotaxin | EC 3.1.4.39 | E-NPP 2 | Extracellular lysophospholipase D | LysoPLD | ATXFLJ26803 | ATX | ATX-X | Autotaxin | autotaxin-t | EC 3.1.4.39 | ectonucleotide pyrophosphatase/phosphodiesterase 2 | ectonucleotide pyrophosphatase/phosphodiesterase fam | ||
| CAS number | unknown | molecular formula | |
| molecular weight | - | Exact mass | 无动物源 |
| PSA | - | logp | - |
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