Hederacolchiside A1, isolated from Pulsatilla chinensis , suppresses proliferation of tumor cells by inducing apoptosis through modulating PI3K/Akt/mTOR signaling pathway Hederacolchiside A1 has antischistosomal activity, affecting parasite viability both in vivo and in vitro . In Vitro Hederacolchiside A1 reduces the mitochondrial membrane potential and Bcl-2 protein levels, whereas cleaved caspase-3 was higher. Hederacolchiside A1 effectively inhibits the phosphorylations of phosphatidylinositol 3 kinase (PI3K), protein kinase B (Akt), and mammalian target of rapamycin (mTOR). MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo hederacolchiside A1 (3.0, 4.5, and 6.0 mg/kg, ip) can significantly inhibit the weight of tumor in an H22 xenograft model . Hederacolchiside A1 (3.25, 7.5, and 15.0 mg/kg, ig) can significantly inhibit the weight of tumor in nude mice xenograft tumor models using human breast carcinoma MCF-7 cells . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:PI3K mTOR
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Hederacolchiside A1
CAS number：106577-39-3 molecular formula：C47H76O16
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| Chinese alias | 常春藤皂苷A1 | ||
| English alias | MS-31671 | Hederacolchiside A1 | (4aS,6aR,6aS,6bR,8aR,10S,12aR,14bS)-10-[(2S,3R,4S,5S)-4-hydroxy-5-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-3-[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxyoxan-2-yl]oxy-2,2,6a,6b,9,9,12a- | ||
| CAS number | 106577-39-3 | molecular formula | C47H76O16 |
| molecular weight | 897.10 g/mol | Exact mass | ≥99% |
| PSA | 255.000 Ų | logp | 3.3 |
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106577-39-3 | Hederacolchiside A1.pdf
