Apelin-12 is one of the most potent C-terminal fragments of the polypeptide that possesses a high affinity to orphan receptor APJ receptor. Apelin-12 is involved in the regulation of body fluid homeostasis and in the central control of feeding. Apelin-12 blocks HIV-1 entry through APJ receptor. Apelin-12 exerts neuroprotective effect In Vitro Apelin-12 (A12) exerts neuroprotective effect against ischemia-reperfusion injury by inhibiting JNK and p38 MAPK signaling pathway in mouse. Administration of exogenous A12 reduces arterial blood pressure in anesthetized rats due to activation of endothelial nitric oxide synthase and exerts a positive inotropic action in failing myocardium of rodents. Apelin-12 stimulates acid secretion through an increase of histamine release in rat stomachs . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:HIV-1
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Apelin-12
CAS number：229961-08-4 molecular formula：C64H103N21O14S
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| Chinese alias | 阿佩林-12 | ||
| English alias | - | ||
| CAS number | 229961-08-4 | molecular formula | C64H103N21O14S |
| molecular weight | 1422.70 g/mol | Exact mass | - |
| PSA | - | logp | - |
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