compound introduction
Valopicitabine (NM283) dihydrochloride is a nucleoside analog and the orally bioavailable proagent of the potent anti-HCV agent 2'-C-methylcytidine (NM107). NM107competitively inhibits NS5B polymerase, causing chain termination. In Vivo Valopicitabine (NM283) (100 mg/kg; oral administration; Sprague-Dawley Rats) dihydrochloride shows the C max , AUC, t 1/2 , and t max were 3.624 μg/mL, 8.95 μg h/mL, 0.64 hours and 1 hour, respectively. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid
