compound introduction
NVP-AEW541(AEW-541)是IGF-1R抑制剂，IC50为86 nM，比对InsR的抑制性强27倍。 NVP-AEW541 is a potent inhibitor of IGF-1R/InsR with IC50 of 150 nM/140 nM in cell-free assays, greater potency and selectivity for IGF-1R in a cell-based assay.
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NVP-AEW541
CAS number：475489-16-8 molecular formula：C27H29N5O
overview
Specs
| Chinese alias | - | ||
| English alias | FT-0744338 | 7-[3-(azetidin-1-ylmethyl)cyclobutyl]-5-(3-phenylmethoxyphenyl)pyrrolo[2,3-d]pyrimidin-4-amine | AECDBHGVIIRMOI-GRGXKFILSA-N | DTXSID60467110 | Q27272024 | NVP-AEW541-A | UNII-AI9WDT80FQ | 7-((1r,3r)-3-(azetidin-1-ylmethyl)cyclobutyl)-5-(3-(b | ||
| CAS number | 475489-16-8 | molecular formula | C27H29N5O |
| molecular weight | 439.55 g/mol | Exact mass | - |
| PSA | 69.200 Ų | logp | 4.2 |
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