CAS number：936091-14-4 molecular formula：C26H35N7O2S
TG101209是JAK2选择性抑制剂，IC50为6 nM，对Flt3和RET的IC50为25 nM和17 nM，比对JAK3的抑制性高30倍，对JAK2V617F和MPLW515L/K突变型敏感，还能抑制BRD4，IC50为130 nM。An inhibitor of JAK2, Flt-3, Ret, and JAK3 TG101209 is a selective JAK2 inhibitor with IC50 of 6 nM, less potent to Flt3 and RET with IC50 of 25 nM and 17 nM, ~30-fold selective for JAK2 than JAK3, sensitive to JAK2V617F and MPLW515L/K mutations; TG101209 inhibit BRD4 activity with IC50 of 130 nM. An inhibitor of JAK2, Flt-3, Ret, and JAK3
| Chinese alias | N-(1,1-二甲基乙基)-3-[[5-甲基-2-[[4-(4-甲基-1-哌嗪基)苯基]氨基]-4-嘧啶基]氨基]苯磺酰胺 | ||
| English alias | NCGC00262608-02 | AC-24600 | N-(tert-Butyl)-3-((5-methyl-2-((4-(4-methylpiperazin-1-yl)phenyl)amino)pyrimidin-4-yl)amino)benzenesulfonamide | Q27162453 | SW219632-1 | CCG-203019 | Kinome_702 | BCP02514 | CHEBI:90304 | CID 16722832 | N-tert-Butyl-3-({5-met | ||
| CAS number | 936091-14-4 | molecular formula | C26H35N7O2S |
| molecular weight | 509.67 g/mol | Exact mass | ≥98% |
| PSA | 111.000 Ų | logp | 4.2 |
No numbering system information yet
No physical and chemical property information yet
No safety information yet
No production method and use information yet
No upstream information yet
No downstream information yet
