CAS number：702675-74-9 molecular formula：C23H26IN7O2S
BX-795是一种有效的，特异性的PDK1抑制剂，IC50为6 nM，作用于PDK1比作用于PKA和PKC选择性分别高140和1600倍。An inhibitor of PDK1, TBK1, and IKK&epsilon BX795 is a potent and specific PDK1 inhibitor with IC50 of 6 nM, 140- and 1600-fold more selective for PDK1 than PKA and PKC, respectively. Meanwhile, in comparison to GSK3β more than 100-fold selectivity observed for PDK1. An inhibitor of PDK1, TBK1, and IKK&epsilon
| Chinese alias | - | ||
| English alias | 5-bromo-1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]pyrimidine-2,4-dione | AKOS016369934 | AS-16196 | 4-(2-bromoethyloxy)-nitrobenzene | HMS3672K09 | BX-795, 3 | N-[3-[[5-iodo-4-[3-(thiophene-2-carbonylamino)propylamino]pyrimidin-2-yl]am | ||
| CAS number | 702675-74-9 | molecular formula | C23H26IN7O2S |
| molecular weight | 591.47 g/mol | Exact mass | - |
| PSA | 140.000 Ų | logp | 4.6 |
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