compound introduction
GSK2606414是口服活性的PERK高活性抑制剂，IC50为0.4 nM。 GSK2606414 is an orally available, potent, and selective PERK inhibitor with IC50 of 0.4 nM, displaying at least 100-fold selectivity over the other EIF2AKs assayed.
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GSK2606414
CAS number：1337531-36-8 molecular formula：C24H20F3N5O
overview
Specs
| Chinese alias | - | ||
| English alias | AC-29016 | 1-(5-(4-amino-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)indolin-1-yl)-2-(3-(trifluoromethyl)phenyl)ethanone | Ethanone, 1-(5-(4-amino-7-methyl-7H-pyrrolo(2,3-d)pyrimidin-5-yl)-2,3-dihydro-1H-indol-1-yl)-2-(3-(trifluoromethyl)phenyl)- | 1-[5-(4-a | ||
| CAS number | 1337531-36-8 | molecular formula | C24H20F3N5O |
| molecular weight | 451.44 g/mol | Exact mass | 10mM in DMSO |
| PSA | 77.000 Ų | logp | 3.800 |
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