Product Application: Protein degrader builiding block Pomalidomide-PEG3-CO2H enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a Cereblon (CRBN)-recruiting ligand and a PEGylated crosslinker with pendant carboxylic acid for reactivity with an amine on the target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a pendant carboxyl group, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.
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Pomalidomide 4'-PEG3-acid
CAS number：2138440-82-9 molecular formula：C22H27N3O9
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compound introduction
Specs
| Chinese alias | 3-[2-[2-[2-[[2-(2,6-二氧代-3-哌啶基)-2,3-二氢-1,3-二氧代-1H-异吲哚-4-基]氨基]乙氧基]乙氧基]乙氧基]丙酸 | ||
| English alias | Pomalidomide - linker 2 | 3-[2-[2-[2-[[2-(2,6-Dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]ethoxy]ethoxy]ethoxy]propanoic acid | Crosslinker−E3 Ligase ligand conjugate | ||
| CAS number | 2138440-82-9 | molecular formula | C22H27N3O9 |
| molecular weight | 477.46 g/mol | Exact mass | ≥95%(HPLC) |
| PSA | 161.000 Ų | logp | -0.1 |
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2138440-82-9 | Pomalidomide-PEG3-CO2H.pdf
