Information GCN2iB GCN2iB is an ATP-competitive serine/threonine-protein kinase general control nonderepressible 2 (GCN2) inhibitor with IC50 of 2.4 nM. Targets GCN2 (Cell-free assay) 2.4 nM Cell Research(from reference) Cell lines:Pancreatic cancer cells, CCRF-CEM cells, MEF cells (GCN2-WT or -KO), CCRF-CEM, MV-4-11, SU.86.86 cells Concentrations:37 nM, 110 nM, 330 nM, 1.0 μM Incubation Time:4 h, 72 h Product Application: GCN2iB is an intermediate used in the preparation of heterocyclic compounds as GCN2 inhibitors.
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GCN2iB
CAS number:2183470-12-2 molecular formula:C18H12ClF2N5O3S
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| Chinese alias | - | ||
| English alias | 3-Pyridinesulfonamide,N-[3-[2-(2-amino-5-pyrimidinyl)ethynyl]-2,4-difluorophenyl]-5-chloro-2-methoxy- | ||
| CAS number | 2183470-12-2 | molecular formula | C18H12ClF2N5O3S |
| molecular weight | 451.83 g/mol | Exact mass | 10mM in DMSO |
| PSA | 128.000 Ų | logp | 2.500 |
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