Information 9-ing-41 9-ING-41 is a potent inhibitor of glycogen synthase kinase-3 (GSK-3) with antitumor activity. 9-ING-41 induces apoptosis and cell cycle arrest at prophase by targeting centrosomes and microtubule-bound GSK3β. Targets GSK-3 In vitro 9-ING-41, a clinically relevant small molecule GSK-3β inhibitor with broad spectrum pre-clinical antitumor activity, suppresses the growth of neuroblastoma cells. 9-ING-41 induces apoptosis and cell cycle arrest at prophase by targeting centrosomes and microtubule-bound GSK3β. In vivo 9-ING-41 has single-agent antitumor activity in a mouse model of MCL. Mouse xenograft studies shows that the combination of clinically relevant doses of CPT-11 and 9-ING-41 lead to greater antitumor effect than is observed with either agent alone. Cell Research(from reference) Cell lines：Neuroblastoma cell lines SK-N-DZ, SK-N-BE Concentrations：0.1 μM–1 μM Incubation Time：48 h
All
Chemical Reagents
Biomedicine
Organic raw materials
Inorganic chemical industry
intermediate
Agricultural chemicals
Auxiliaries and catalysts
Fragrances and Flavors
Dyes and Pigments
Daily chemical industry
9-ing-41
CAS number：1034895-42-5 molecular formula：C22H13FN2O5
overview
compound introduction
Specs
| Chinese alias | - | ||
| English alias | 3-(5-FLUORO-1-BENZOFURAN-3-YL)-4-(5-METHYL-5H- (1,3)DIOXOLO(4,5-F)INDOL-7-YL)-1H-PYRROLE-2,5-DIONE | WHO 11553 | 2-(hydroxymethyl)-isoindole-1,3-dione | ND1SOF0DLU | EX-A4074 | 3-(5-Fluoro-benzofuran-3-yl)-4-(5-methyl-5H-(1,3)dioxolo(4,5-F)indol-7-yl)-pyr | ||
| CAS number | 1034895-42-5 | molecular formula | C22H13FN2O5 |
| molecular weight | 404.35 g/mol | Exact mass | - |
| PSA | 82.700 Ų | logp | 3.339 |
numbering system
No numbering system information yet
physicochemical properties
No physical and chemical property information yet
Safety information
No safety information yet
Production methods and uses
No production method and use information yet
Related
upstream information
No upstream information yet
downstream information
No downstream information yet
MSDS
Found 0 shareMSDS
