Tenovin-6 Hydrochloride, an analog of Tenovin-1 , is an activator of p53 transcriptional activity. Tenovin-6 Hydrochloride inhibits the protein deacetylase activities of purified human SIRT1 , SIRT2 , and SIRT3 with IC 50 s of 21 μM, 10 μM, and 67 μM, respectively. Tenovin-6 Hydrochloride also inhibits dihydroorotate dehydrogenase (DHODH) In Vitro Tenovin-6 Hydrochloride inhibits the growth of S. cerevisiae cultures with an IC50 of 30 μM and is more toxic to yeast than the less water-soluble tenovin-1. Tenovin-6 Hydrochloride rapidly increases the levels of endogenous K382-Ac p53 in MCF-7 cells. Tenovin-6 Hydrochloride (0 to 15 μM) dose dependently increases the level of LC3-II in diverse cell types, and the increase is ATG5/7 dependent. Tenovin-6 Hydrochloride treatment also increases the number and intensity of autophagic vesicles with or without the presence of Torin 1, and prevents Torin 1-induced SQSTM1/p62 degradation. Tenovin-6 Hydrochloride affects the acidification of autolysosomes and impairs the hydrolytic activity of lysosomes but does not affect the fusion between autophagosomes and lysosomes. That Tenovin-6 Hydrochloride inhibits autophagy does not correlate with p53 activation and SIRT1/2 inhibition by knockdown or knockout cannot mimic the effect of Tenovin-6 Hydrochloride on LC3B accumulation. Tenovin-6 Hydrochloride (0, 1, 2.5, 5 or 10 μM) potently inhibits cell proliferation in a dose- and time-dependent manner in all OCI-Ly1, DHL-10, U2932, RIVA, HBL1 and OCI-Ly10 cell lines. Tenovin-6 Hydrochloride consistently increases LC3B-II level in DLBCL cell lines by inhibiting the classical autophagy pathway, without activating p53, and the increase is independent of SIRT1/2/3 and p53. Tenovin-6 Hydrochloride induces apoptosis through the extrinsic cell-death pathway [4 . Tenovin-6 Hydrochloride suppresses the growth of UM cells with IC50 of 12.8 μM, 11.0 μM, 14.58 μM and 9.62 μM for 92.1, Mel 270, Omm 1 and Omm 2.3 cells, respectively . MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo Tenovin-6 Hydrochloride (50 mg/kg, i.p.) inhibits the growth of tumor in mice . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:SIRT2 10 μM (IC 50 ) SIRT1 21 μM (IC 50 ) SIRT3 67 μM (IC 50 ) HDAC8 MDM-2/p53
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Tenovin-6 Hydrochloride
CAS number：1011301-29-3 molecular formula：C25H35ClN4O2S
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| Chinese alias | Tenovin-6 盐酸盐 | ||
| English alias | SCHEMBL907346 | Tenovin 2 | 4-(Tert-butyl)-N-((4-(5-(dimethylamino)pentanamido)phenyl)carbamothioyl)benzamide hydrochloride | AKOS030526197 | CCG-269623 | BCP18122 | 1011301-29-3 | AC-36468 | Tenovin-6 (Hydrochloride) | A921712 | F85008 | MS-29130 | HY-15 | ||
| CAS number | 1011301-29-3 | molecular formula | C25H35ClN4O2S |
| molecular weight | 491.09 g/mol | Exact mass | ≥98% |
| PSA | 106.000 Ų | logp | - |
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