AC-73 是Cluster of Differentiation 147 (CD147)的第一种特定的口服生物利用的抑制剂,可特异性破坏CD147的二聚化 (结合位点在CD147的 N 端 IgC2 域中包括 Glu64 和 Glu73),从而抑制CD147/ERK1/2/STAT3/MMP-2 途径,并抑制肝癌细胞的运动和侵袭。AC-73 还是一种抗增殖药,也是白血病细胞自噬的诱导剂。
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3-[1-Hydroxy-2-[(4-phenylphenyl)methylamino]ethyl]phenol
CAS number:775294-71-8 molecular formula:C21H21NO2
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| Chinese alias | - | ||
| English alias | - | ||
| CAS number | 775294-71-8 | molecular formula | C21H21NO2 |
| molecular weight | 319.4 g/mol | Exact mass | ≥99% |
| PSA | 52.500 Ų | logp | 2.8 |
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