CAS number：778576-62-8 molecular formula：C20H13Cl2F2N3O5S
Oglemilast (GRC 3886) 是一种具有口服活性磷酸二酯酶 4 (PDE4) 抑制剂，对 PDE4D3 的 IC50 为 0.5 nM。Oglemilast 在体外和体内抑制肺细胞浸润，包括嗜酸性粒细胞增多和嗜中性粒细胞减少。Oglemilast 具有应用于炎症性气道疾病的潜力。 Oglemilast (GRC 3886) is a potent and orally active phosphodiesterase-4 (PDE4) inhibitor with an IC50 of 0.5 nM for PDE4D3. Oglemilast inhibits pulmonary cell infiltration, including eosinophilia and neutrophilia in vitro and in vivo. Oglemilast has the potential for inflammatory airway diseases.
| Chinese alias | - | ||
| English alias | BCP21392 | UNII-67GXQ6WCC6 | NCGC00379066-01 | GRC3886 | GRC-3886 | 4-difluoromethoxy-8-methanesulfonylamino-dibenzofuran-1-carboxylic acid (3,5-dichloro-pyridin-4-yl)-amide | N-(3,5-Dichloropyridin-4(1H)-ylidene)-4-(difluoromethoxy)-8-[(methanesulfonyl)a | ||
| CAS number | 778576-62-8 | molecular formula | C20H13Cl2F2N3O5S |
| molecular weight | 516.30 g/mol | Exact mass | ≥98% |
| PSA | 119.000 Ų | logp | 4.6 |
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