Purity:>90%, by SDS-PAGE visualized with Coomassie® Blue Staining. Description： Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Required for checkpoint-mediated arrest of cell cycle progression in response to low doses of ionizing radiation and for efficient repair of DNA double strand breaks (DSBs) specifically when modified by C-terminal phosphorylation.
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Recombinant Human Histone H2AX Protein
CAS number：unknown molecular formula：
overview
compound introduction
Specs
| Chinese alias | 重组人Histone H2AX蛋白 | 重组人类组蛋白 H2AX 蛋白 | ||
| English alias | AW228881 | H2A histone family member X | H2A.FX | H2A.X | H2a/x | H2AFX | H2AX | H2AX histone | H2AX_HUMAN | Hist5.2ax | Histone 2AX | Histone 2A | Histone H2A.X | Histone H2AX | RGD1566119 | ||
| CAS number | unknown | molecular formula | |
| molecular weight | - | Exact mass | 无载体 |
| PSA | - | logp | - |
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