compound introduction
GW441756 是一种有效的，选择性的TrkA抑制剂，IC50为2 nM，对c-Raf1和CDK2几乎没有抑制活性。GW441756 可增加caspase-3并诱导凋亡。
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GW441756
Dangerous GoodsCAS number：504433-23-2 molecular formula：C17H13N3O
overview
Specs
| Chinese alias | - | ||
| English alias | GW441756 hydrochloride | 3-(1-Methyl-1H-indol-3-ylmethylene)-1,3-dihydro-pyrrolo[3,2-b]pyridin-2-one | BRD-K04146668-001-01-3 | HMS3303P17 | HMS3305D02 | DTXSID90858850 | CHEBI:92072 | (3Z)-3-[(1-methylindol-3-yl)methylidene]-1H-pyrrolo[3,2-b]pyridin-2-on | ||
| CAS number | 504433-23-2 | molecular formula | C17H13N3O |
| molecular weight | 275.3 g/mol | Exact mass | 10mM in DMSO |
| PSA | 46.900 Ų | logp | 1.900 |
numbering system
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physicochemical properties
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Safety information
pictogram：
GHS07
Signal word：
Warning
Hazard Statement：
H315: 引起皮肤刺激 H319: 引起严重眼睛刺激 H335: 可能引起呼吸道刺激
Statement of Preventive Measures：
P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾 P305+P351+P338: 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。 P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P302+P352: 如皮肤沾染：用水充分清洗。 P321: 特殊处理（请参阅此标签上的...）。 P405: 密闭存放 P501: 将内容物/容器处理到。。。 P264: 处理后要彻底洗手。 P271: 仅在室外或通风良好的地方使用。 P304+P340: 如误吸入：将人转移
Production methods and uses
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upstream information
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downstream information
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MSDS
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