Thailanstatin A is an ultra-potent inhibitor of eukaryotic RNA splicing ( IC 50 =650 nM). Thailanstatin A exerts effects via non-covalent binding to the SF3b subunit of the U2 snRNA subcomplex of the spliceosome and shows low-nM to sub-nM IC 50 s against multiple cancer cell lines. Thailanstatin A, a payload for ADCs, is conjugated to the lysines on trastuzumab yielding “linker-less” ADC . In Vitro Thailanstatin A (TST-A) is a potent antiproliferative natural product, can be discovered from Burkholderia thailandensis MSMB43. ? Thailanstatin A (DU-145, NCI-H232A, MDA-MB-231 and SKOV-3 cells) exhibits potent antiproliferative activities with GI 50 s in the single nM range (1.11-2.69 nM). MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid
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Thailanstatin A
CAS number：1426953-21-0 molecular formula：C28H41NO9
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| Chinese alias | 泰兰他汀A | ||
| English alias | - | ||
| CAS number | 1426953-21-0 | molecular formula | C28H41NO9 |
| molecular weight | 535.63 g/mol | Exact mass | ≥98% |
| PSA | 144.000 Ų | logp | 1.9 |
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