MMAF-d 8 (hydrochloride)e is a deuterated form of MMAF hydrochloride, which is a microtubule disrupting agent. Appearance:Solid IC50& Target:Auristatin In Vitro:MMAF shows in vitro cytotoxicity against a panel of cell lines. The IC 50 values for Karpas 299, H3396, 786-O and Caki-1 are 119, 105, 257, and 200 nM, respectively. Targeted MMAF is much more potent than the free drug, and that cAC10 conjugates of MMAF d In Vivo:The maximum tolerated dose in mice of MMAF (>16mg/kg) is much higher than MMAE (1mg/kg). cAC10-L1-MMAF 4 has an MTD of 50mg/kg in mice and 15mg/kg in rats. The corresponding cAC10-L4-MMAF 4 ADC was much less toxic, having MTDs in mice and rats of >150 Biological Activity:MMAF-d 8 (hydrochloride)e is a deuterated form of MMAF hydrochloride, which is a microtubule disrupting agent.
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MMAF-d8hydrochloride
CAS number：unknown molecular formula：C39H58D8ClN5O8
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| Chinese alias | MMAF-d8盐酸盐 | ||
| English alias | - | ||
| CAS number | unknown | molecular formula | C39H58D8ClN5O8 |
| molecular weight | 776.47 g/mol | Exact mass | ≥99% |
| PSA | - | logp | - |
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