compound introduction
Fmoc-NH-ethyl-SS-propionic acid 是一种可降解 (cleavable) 的 ADC linker，可用于合成抗体偶联活性分子 (ADC)。Fmoc-NH-乙基-SS-丙酸含有Fmoc保护基团和NHS酯基团。Fmoc保护基可以在碱性条件下除去，得到游离胺，其可用于进一步缀合。使用EDC和DCC等活化剂时，酸基可以与伯胺反应，形成稳定的酰胺键。 Fmoc-NH-ethyl-SS-propionic acid is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).Fmoc-NH-ethyl-SS-propionic acid contains an Fmoc protecting group and an NHS ester group. The Fmoc protecting group can be removed under basic condition to obtain a free amine which can be used for further conjugations. The acid group can react with primary amines upon the use of activators such as EDC and DCC to form stable amide bonds.
