compound introduction
LOC14 是蛋白质二硫键异构酶 (PDI) 抑制剂 (EC50=500 nM; Kd=62 nM)。LOC14 在小鼠肝微粒体和血浆中表现出高稳定性，低内在微粒体清除率和低血浆蛋白结合。LOC14 抑制 PDIA3 活性，降低肺上皮细胞中 HA 的分子内二硫键和随后的寡聚化。
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LOC14
CAS number：877963-94-5 molecular formula：C16H19N3O2S
overview
Specs
| Chinese alias | - | ||
| English alias | - | ||
| CAS number | 877963-94-5 | molecular formula | C16H19N3O2S |
| molecular weight | 317.41 g/mol | Exact mass | 10mM in DMSO |
| PSA | 69.200 Ų | logp | 1.300 |
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