CAS number：929634-33-3 molecular formula：C16H11ClF3N3OS3
ADAMTS-5抑制剂是具有Zn | 2+ |螯合结构基序的硫代噻唑啉酮化合物，可作为ADAMTS-5（aggrecanase-2）抑制剂（IC | 50 | = 1.1μM），其选择性是ADAMTS的40倍左右-4（aggrecanase-1）。 ADAMTS-5 Inhibitor is a thioxothiazolidinone compound that possesses a Zn|2+|-chelating structural motif and acts as an ADAMTS-5 (aggrecanase-2) inhibitor (IC|50|= 1.1 μM) with ~40-fold selectivity over ADAMTS-4 (aggrecanase-1).
| Chinese alias | - | ||
| English alias | 5-((4-Chlorobenzylthio-3-trifluoromethyl-N-methyl-1H-pyrazol-4-yl)methylene)-2-thioxothiazolidin-4-one | ||
| CAS number | 929634-33-3 | molecular formula | C16H11ClF3N3OS3 |
| molecular weight | 449.92 g/mol | Exact mass | ≥98% |
| PSA | 130.000 Ų | logp | 5 |
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