Resolvin D1

Resolvin D1来自二十碳五烯酸（EPA）和二十二碳六烯酸（DHA）（1）衍生的有效脂质介体家族，它是一种抗炎药，可促进炎症反应恢复为非炎性状态。2 RvD1是由DHA被15-和5-脂氧合酶顺序氧化而产生的。它可减少人多形核白细胞（PMNL）的跨内皮迁移，这是急性炎症中的最早事件，其EC50值为〜30 nM。在鼠腹膜炎模型中，它表现出白细胞浸润的剂量依赖性降低，在10-100 ng剂量下最大抑制率约为35％。 该产品浓度为100ug/mL Resolvin D1 is from a family of potent lipid mediators derived from both eicosapentaenoic acid (EPA) and docosahexaenoic (DHA)(1), it is an anti-inflammatory and promotes the resolution of the inflammatory response back to a non-inflamed state.2 RvD1 is produced physiologically from the sequential oxygenation of DHA by 15- and 5-lipoxygenase. It reduces human polymorphonuclear leukocyte (PMNL) transendothelial migration, the earliest event in acute inflammation, with EC50 values of ~30 nM. It exhibits a dose-dependent reduction in leukocyte infiltration in a murine model of peritonitis with a maximal inhibition of ~35% at a 10-100 ng dose. Resolvin D1 (RvD1) is supplied as a solution in ethanol. To change the solvent, simply evaporate the ethanol under a gentle stream of nitrogen and immediately add the solvent of choice. It is recommended that this product be stored and handled in an ethanol solution. Resolvins can isomerize and degrade when put into freeze thaw conditions and/or in solvents such as dimethyl formamide or DMSO.

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