compound introduction
比马前列酰胺是F系列前列腺素（PG）类似物，其中C-1羧基已被修饰为未取代的酰胺。目前正在研究这种和其他PG N-乙基酰胺作为PG降压药的替代品。预计比马前列素酰胺会表现出拉坦前列素的典型眼内作用，而PG N-酰胺的水解药代动力学要慢得多。 Bimatoprost amide is an F-series prostaglandin (PG) analog in which the C-1 carboxyl group has been modified to an unsubstituted amide. This and other PG N-ethyl amides are being researched as alternative PG hypotensive prodrugs. Bimatoprost amide would be expected to show the typical intraocular effects of latanoprost with the much slower hydrolysis pharmacokinetics of a PG N-amide.
