CAS number：331862-41-0 molecular formula：C13H11NO5S2
IMR-1A 是 IMR-1 的酸代谢物，一种有效的 Notch 抑制剂，IC50 为 0.5 μM。IMR-1A 相对于 IMR-1 的效力增加了 50 倍。IMR-1 在体内可以代谢为 IMR-1A。 Information IMR-1A IMR-1A, an acid metabolite of IMR-1, is a potent inhibitor of Notch with IC50 of 0.5 μM and Kd of 2.9 μM. IMR-1A exhibits anti-tumor activity. Targets Notch (Cell-free assay); Notch (Cell-free assay) 0.5 μM; 2.9 μM(Kd)
| Chinese alias | - | ||
| English alias | Acetic acid,2-[2-methoxy-4-[(4-oxo-2-thioxo-5-thiazolidinylidene)methyl]phenoxy]- | ||
| CAS number | 331862-41-0 | molecular formula | C13H11NO5S2 |
| molecular weight | 325.36 g/mol | Exact mass | 10mM in DMSO |
| PSA | - | logp | 2.29 |
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