compound introduction
HS-27，一种荧光Hsp90抑制剂，检测完整组织标本表面Hsp90的表达。HS-27由SNX-5422的核心元素组成，SNX-5422是一种Hsp90抑制剂，通过PEG连接物与荧光素衍生物(异硫氰酸荧光素或FITC)连接，后者与外周表达的Hsp90结合。HS-27在乳腺癌的观察与研究中有潜在的应用 Information HS-27 is a fluorescently-tethered Hsp90 inhibitor that assays surface Hsp90 expression on intact tissue specimens. HS-27 consists of the core elements of SNX-5422 (Hsp90 inhibitor) and a fluorescein derivative (fluorescein isothiocyanate or FITC) via a PEG linker. HS-27 is potentially used in a see-and-treat paradigm in breast cancer.
