MA-0204 是一种有效,高选择性,有口服活性的的过氧化物酶体增殖物激活受体 δ (PPARδ) 调节剂,对于人,小鼠和大鼠 PPARδ 的 EC50 分别为 0.4 nM、7.9 nM 和 10 nM。有研究 Duchene 肌营养不良症 (DMD) 的潜力。 Information MA-0204 is a potent, highly selective and orally available modulator of peroxisome proliferator activated receptor δ (PPARδ) with EC50 of 0.4 nM, 7.9 nM and 10 nM for human, mouse and rat PPARδ, respectively. MA-0204 is used as a potential treatment for Duchene Muscular Dystrophy (DMD).
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MA-0204
CAS number:2095128-17-7 molecular formula:C25H27F3N2O4
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| Chinese alias | - | ||
| English alias | (R)-3-methyl-6-(2-((5-methyl-2-(4-(trifluoromethoxy)phenyl)-1H-imidazol-1-yl)methyl)phenoxy)hexanoic acid | ||
| CAS number | 2095128-17-7 | molecular formula | C25H27F3N2O4 |
| molecular weight | 476.49 g/mol | Exact mass | - |
| PSA | 73.600 Ų | logp | 5.8 |
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