CAS number：1628805-46-8 molecular formula：C23H22F4N6O2
Information IDH-305 IDH-305 (Compound 13) is an orally available, mutant-selective and brain-penetrant inhibitor of isocitrate dehydrogenase 1 (IDH1) that targets IDH1(R132) mutation with IC50 of 27 nM, 28 nM and 6.14 μM for IDH1 R132H , IDH1 R132C and IDH1 WT , respectively. Targets IDH1 R132H (Cell-free assay); IDH1 R132C (Cell-free assay); IDH1 WT (Cell-free assay) 27 nM; 28 nM; 6.14 μM
| Chinese alias | - | ||
| English alias | 2-OXAZOLIDINONE, 4-((1S)-1-FLUOROETHYL)-3-(2-(((1S)-1-(4-METHYL-2'-(TRIFLUOROMETHYL)(3,4'-BIPYRIDIN)-6-YL)ETHYL)AMINO)-4-PYRIMIDINYL)-, (4R)- | UNII-A791KH7YZW | MFCD31630851 | NSC812928 | NSC-812928 | A16943 | P18095 | 1628805-46-8 | AKOS040741865 | (4R) | ||
| CAS number | 1628805-46-8 | molecular formula | C23H22F4N6O2 |
| molecular weight | 490.45 g/mol | Exact mass | ≥98% |
| PSA | 93.100 Ų | logp | 3.9 |
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