Sacubitril/Valsartan (LCZ696) 是由 Valsartan (an ARB) 和 Sacubitril (AHU377) 组成，摩尔比为 1:1，是一种首创的血管紧张素受体-脑啡肽酶 (ARN) 双抑制剂，用于研究高血压和心力衰竭。它可通过抑制炎症、氧化应激和细胞凋亡来改善糖尿性心肌病 Information Sacubitril/valsartan (LCZ696) Sacubitril/valsartan (LCZ696, Sacubitril, Valsartan), consisting of valsartan and sacubitril in 1:1 molar ratio, is an orally bioavailable, dual-acting angiotensin receptor-neprilysin inhibitor (ARNi) for hypertension and heart failure. Phase 3. Targets RAAS In vivo In double-transgenic rats overexpressing human renin and angiotensinogen and plasma atrial natriuretic peptide immunoreactivity, LCZ696 (60 mg/kg p.o.) induces a dose-dependent and long-lasting reduction in mean arterial pressure (MAP), and stimulates a rapid and dose-dependent augmentation of plasma ANP immunoreactivity. In rat myocardial infarction (MI) model, LCZ696 (68 mg/kg p.o.) attenuates cardiac remodeling and dysfunction after myocardial infarction by reducing cardiac fibrosis and hypertrophy.
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Sacubitril/valsartan (LCZ696)
CAS number：936623-90-4 molecular formula：C24H29N5O3·C24H29NO5·5/2H2O·3Na
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| Chinese alias | - | ||
| English alias | Sacubitril mixture with Valsartan | Valsartan | Sacubitril | LCZ696 | ||
| CAS number | 936623-90-4 | molecular formula | C24H29N5O3·C24H29NO5·5/2H2O·3Na |
| molecular weight | 915.98 g/mol | Exact mass | ≥99% |
| PSA | - | logp | - |
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